Ronald M. Evans, Ph.D.
Institutional Affiliation:
Investigator, Howard Hughes Medical Institute
Professor, The Salk Institute for Biological Studies
March of Dimes Chair in Molecular and Developmental Biology
http://www.hhmi.org/research/investigators/evans_bio.html
http://www.salk.edu/faculty/evans.html
Education
University of California, Los Angeles, B.A.
University of California, Los Angeles, Ph.D.
Postdoctoral Work
The Rockefeller University
Research
Pharmacogenetic Characterization of the Nuclear Hormone Receptors PPARĪ³ and PPARĪ“ in the Development of Colorectal Cancer
Impact
The aim of our research is to understand how inflammatory and dietary signals cause colorectal cancer. Insight into the genes that are involved and how they work might ultimately lead to the prevention and treatment of this disease.
Summary of Research
Colorectal cancer (CRC) is the third most common cancer in humans and the second leading cause of cancer-related death in the Western world. Its prevalence is increasing and is associated with the Western life-style, which is characterized by a high fat diet, lack of exercise and obesity. CRC is also linked to (chronic) inflammation as patients with inflammatory bowel disease -either Crohn's disease or ulcerative colitis- are at increased risk for developing CRC. The aim of our research is to understand how inflammatory and dietary signals cause CRC. Insight into the genes that are involved and how they work might ultimately lead to the prevention and treatment of this disease. |
