Yongkui Jing, Ph.D.
Institutional Affiliation:
Associate Professor
Mount Sinai School of Medicine
http://www.mountsinai.org/Find%20A%20Faculty/profile.do?id=0000072500001497225902&officeDrawer=biz
Education
Peking Union Medical University and Chinese Academy of Medical Sciences, China, Ph.D.
Postdoctoral Work
Mount Sinai School of Medicine
Research
Selectively Targeting Acute Myeloid Leukemia
Impact
Selectively inducing cell death in myeloid leukemia by producing reactive oxygen species.
Summary of Research
Acute myeloid leukemia (AML) cells like normal white blood cells have the ability to generate reactive oxygen species (ROS) which kill bacteria and induce cell toxicity. AML cells have low levels of catalase and glutathione peroxidase, two key enzymes to detoxify ROS, and are more susceptible to ROS-induced cell death. We found that arsenic trioxide, a drug use for treatment of acute promyelocytic leukemia, induces more ROS production and selectively kills a variety of AML cells in combination with agents which inhibits the activity of anti-death proteins. These combinations would have therapeutic potential for the treatment of AML patients. |
