Scientific Advisory Board
Guiding the SWCRF Research and Science Programs
Adolfo Ferrando, MD, PhD
Institute for Cancer Genetics, Columbia University
Professor of Pediatrics and Pathology & Cell Biology
Associate Director for Research, Pediatric Oncology Division
Director Lymphoid Development and Malignancies Program, Herbert Irving Cancer Center
Adolfo Ferrando, MD, PhD, Institute for Cancer Genetics, Columbia University, is Professor of Pediatrics and Pathology & Cell Biology, Associate Director for Research in the Pediatric Oncology Division and Director of the Lymphoid Development and Malignancies Program at the Herbert Irving Comprehensive Cancer Center. Dr. Ferrando received his MD and PhD from the University of Oviedo in Spain and completed his postdoctoral training at Dana Farber Cancer Research Institute in Boston. Dr. Ferrando’s research program combines genomics, biochemical, genetic and experimental therapeutics approaches towards the identification of novel therapies for the treatment of high risk leukemias and lymphomas. He has been the recipient of several honors and awards, most recently the Pershing Square Sohn Prize for Young Investigators in Cancer Research in 2014 and the V National "Doctores Diz Pintado" Cancer Research Prize in 2015. He is member the American Society of Clinical Investigation and currently serves in the editorial board of Leukemia, Cancer Research.
Recent relevant publications:
Dieck CL, Tzoneva G, Forouhar F, Carpenter Z, Ambesi-Impiombato A, Sánchez-Martín M, Kirschner Schwabe M, Lew S, Seetharaman J, Tong L and Ferrando AA. Structure and mechanisms of NT5C2 mutations driving thiopurine resistance in relapsed lymphoblastic leukemia. Cancer Cell. 2018; 34, 136–147.
Tzoneva G, Dieck CL, Oshima K, Ambesi-Impiombato A, Sánchez-Martín M, Madubata CJ, Khiabanian H, Yu J, Waanders E, Iacobucci I, Sulis ML, Kato M, Koh K, Paganin M, Basso G, Gastier-Foster JM, Loh ML, Kirschner-Schwabe R, Mullighan CG, Rabadan R, and Ferrando AA Clonal evolution mechanisms in NT5C2-mutant relapsed acute lymphoblastic leukemia. Nature 2018 553:511-514.
Steven Gore, M.D.
Professor of Internal Medicine (Hematology); Director of Hematologic Malignancies
Yale Cancer Center: Developmental Therapeutics | Hematology Program | K12 Calabresi Immuno-Oncology Training Program (IOTP)
Dr. Gore served as a Professor of Oncology at The Johns Hopkins School of Medicine and was a Faculty Member in their Cell and Molecular Medicine Program. He is a member of the American Society of Hematology, the American Society of Clinical Oncology, and the American Association for Cancer Research. Dr. Gore is a member of the Leukemia Core Committee and the Leukemia Correlative Science Committee of the Eastern Cooperative Oncology Group. He also Chairs the Hematologic Malignancies Committee of the Mayo Phase 2 Consortium.
Recent relevant publications:
Chandhok NS, Boddu PC, Gore SD, Prebet T: What are the most promising new agents in myelodysplastic syndromes? Curr Opin Hematol. 2019 Jan 9; 2019 Jan 9. PMID: 30632987
Huntington SF, Hoag JR, Zhu W, Wang R, Zeidan AM, Giri S, Podoltsev NA, Gore SD, Ma X, Gross CP, Davidoff AJ: Oncologist volume and outcomes in older adults diagnosed with diffuse large B cell lymphoma. Cancer. 2018 Nov 1; 2018 Sep 14. PMID: 30216436
Podoltsev NA, Zhu M, Zeidan AM, Wang R, Wang X, Davidoff AJ, Huntington SF, Giri S, Gore SD, Ma X: The impact of phlebotomy and hydroxyurea on survival and risk of thrombosis among older patients with polycythemia vera. Blood Adv. 2018 Oct 23. PMID: 30333100
Ball B, Komrokji RS, Adès L, Sekeres MA, DeZern AE, Pleyer L, Vey N, Almeida A, Germing U, Cluzeau T, Platzbecker U, Gore SD, Fenaux P, Prebet T: Evaluation of induction chemotherapies after hypomethylating agent failure in myelodysplastic syndromes and acute myeloid leukemia. Blood Adv. 2018 Aug 28. PMID: 30120104
Stahl M, DeVeaux M, Montesinos P, Itzykson R, Ritchie EK, Sekeres MA, Majhail N, Barnard J, Podoltsev NA, Brunner AM, Komrokji RS, Bhatt VR, Al-Kali A, Cluzeau T, Santini V, Roboz GJ, Fenaux P, Litzow M, Fathi AT, Perreault S, Kim TK, Prebet T, Vey N, Verma V, Kobbe G, Bergua J, Serrano J, Gore SD, Zeidan AM: Allogeneic Hematopoietic Stem Cell Transplantation Following the Use of Hypomethylating Agents among Patients with Relapsed or Refractory AML: Findings from an International Retrospective Study. Biol Blood Marrow Transplant. 2018 Aug; 2018 Apr 9. PMID: 29649620
Zeidan AM, Knaus HA, Robinson TM, Towlerton AMH, Warren EH, Zeidner JF, Blackford AL, Duffield AS, Rizzieri D, Frattini MG, Levy YM, Schroeder MA, Ferguson A, Sheldon KE, DeZern AE, Gojo I, Gore SD, Streicher H, Luznik L, Smith BD: A Multi-center Phase I Trial of Ipilimumab in Patients with Myelodysplastic Syndromes following
Hypomethylating Agent Failure. Clin Cancer Res. 2018 Aug 1; 2018 May 1. PMID: 29716921
Lorraine J. Gudas, Ph.D.
Department of Pharmacology, Weill Cornell Medical College
Epigenetics of stem cell differentiation; retinoid pharmacology; head and neck squamous cell carcinoma; mitochondrial function in kidney cancer
Current Reseach Interest
The molecular regulation of the differentiation of embryonic stem cells. The molecular mechanisms of action of retinoids (vitamin A and related molecules) in the regulation of cell differentiation and the inhibition of neoplastic transformation. Analysis of retinoid metabolism and signaling in normal and tumor cells. Delineation of the role of the enzyme LRAT (lecithin:retinol acyltransferase) in vitamin A (retinol) uptake and storage, and characterization of the mechanism by which LRAT expression is lost in human tumor cells. The functional analysis of the transcription factor Rex1 (Zfp42), a marker of embryonic stem cells. Development of new mouse models for kidney cancer and head and neck cancer. Understanding how vitamin A deficiency in mice causes hyperglycemia and loss of pancreatic beta cell mass. Development of new drugs for diabetes and fatty liver disease.
1. Quintero CM, Laursen KB, Mongan NP, Luo M, and Gudas LJ. (2018) CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation. J Mol Biol. In press. PMID: 30153436
2. Trasino SE, Tang XH, Shevchuk MM, Choi ME, and Gudas LJ. (2018) Amelioration of diabetic nephropathy using a retinoic acid receptor β2 agonist. J Pharmacol Exp Ther. 367(1):82-94. PMID: 30054312. PMC6123666.
3. Sureshbabu A, Patino E, Ma K, Laursen K, Finkelsztein E, Akchurin O, Thangamini M, Ryter SW, Gudas LJ, Choi, AMK, Choi ME. (2018) RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction. JCI Insight. 3(11):98411. PMID: 29875323. PMC6124406.
4. Trasino SE, Tang XH, Jessurun J, and Gudas LJ. (2016) A retinoic acid receptor β2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease. J Mol Med. 94(10):1143-51. PMID: 27271256. PMC5053866.
Ramon Parsons, MD, PhD
Ward Coleman Professor in Cancer Research
Director, Tisch Cancer Institute at Mount Sinai
Director, Mount Sinai Cancer, Mount Sinai Health System
Chairman of the Department of Oncological Sciences at the Icahn School of Medicine at Mount Sinai
Ramon Parsons received his education at Columbia University (A.B., 1983), State University of New York at Stony Brook (M.D.-Ph.D., 1984-1992), and Johns Hopkins University (postdoctoral fellowship, 1992-1995). Dr. Parsons joined the faculty of the Departments of Pathology and Medicine at Columbia University as an Assistant Professor in 1995 and was promoted to the the Avon Foundation Chair for Breast Cancer Research in 2002, Professor in 2007, and Leader of its Breast Cancer Program Herbert Irving Comprehensive Cancer Center in 2005. In 2013 he transitioned to Icahn School of Medicine at Mount Sinai to Chair the Department of Oncological Sciences where he is an Icahn Scholar and the Ward-Coleman Professor in Cancer Research. In 2017, he was appointed Director of the NCI-designated Tisch Cancer Institute at Mount Sinai and the Director of Mount Sinai Cancer for the Mount Sinai Health System after serving as the co-Leader of the Cancer Mechanisms program and the Deputy Director. Dr. Parsons maintains an active laboratory and has received multiple awards for his research, including the 2011 AACR Outstanding Investigator Award for Breast Cancer Research and is a member of the American Society for Clinical Investigation, the American College of Physicians, and the National Academy of Medicine. He was the Chair of the AACR Special conferences committee for two terms from 2011-2017, which initiated and planned over 75 scientific meetings on different cancer related topics.
Dr. Parsons is internationally recognized as an expert in the fields of cancer genetics and signal transduction. Dr. Parsons’ graduate work established the molecular mechanism through which Large T Antigen unwinds the SV40 virus core origin of replication (Parsons et al. J. Virology 1988, 1989, 1990). His postdoctoral fellowship established the role of defective DNA mismatch repair in the development of colon cancer and a genetic test for detecting mutation burden (Parsons et al. Cell 1993; Parsons et al. Science 1995; Parsons et al. Cancer Research 1995; Liu et al. Nature Medicine 1995). In 1997 after establishing his own laboratory, he discovered the tumor suppressor located on chromosome 10q23, named it Phosphatase and Tensin Homolog on Chromosome Ten (PTEN), and showed that PTEN is mutated in a wide variety of cancers and inherited cancer predisposition syndromes (Li et al., Science 1997; Liaw et al., Nature Genetics 1997). He then demonstrated that restoring wild type PTEN expression in mutant PTEN tumor cell lines inhibited phosphoinositide 3’-kinase (PI3K) signaling to induce cell death that could be rescued by activated AKT (Li et al., Cancer Research 1998). He showed that
Martin S. Tallman, M.D.
Martin S. Tallman, M.D. is Chief, Leukemia Service at Memorial Sloan Kettering Cancer Center and Professor of Medicine at Weill Cornell Medical College in New York, USA. He is a diplomate of the American Board of Internal Medicine with sub-specialty certification in the areas of hematology and medical oncology.
He served as Chair of the Leukemia Committee of the Eastern Cooperative Oncology Group for 16 years. Dr. Tallman received his bachelor’s degree in Science at the University of Michigan in Ann Arbor, Michigan, USA and his medical degree at The Chicago Medical School in Chicago, Illinois, USA. After completing an internship, residencies, and chief residency at McGraw Medical Center at Northwestern University, Dr. Tallman completed his fellowship in hematology/oncology at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle, Washington, USA. Dr. Tallman is a member of numerous committees of national, regional, and international professional societies involved in the study and treatment of cancer, including the American Society of Hematology, American Society of Clinical Oncology, and the Eastern Cooperative Oncology Group. He currently serves as Co-Chair of the Acute Myeloid Leukemia Panel of the National Comprehensive Cancer Network (NCCN). Dr. Tallman has contributed a large body of work to the literature addressing the diagnosis, biology, and treatment of acute leukemia and other hematologic malignancies. This work includes original research articles in peer-reviewed journals, textbook chapters and reviews, monographs, editorials, and abstracts. He has spoken as an invited lecturer and chair at many national and international symposia, conferences, and meetings, including the American Society of Hematology Meeting, the American Society of Clinical Oncology Meeting, and the CIBMTR Tandem Annual Meeting. Dr. Tallman completed two terms as an Associate Editor of Blood. He is a reviewer for many professional publications, including American Journal of Hematology, Annuals of Internal Medicine, Bone Marrow Transplantation, Cancer Research, Journal of Clinical Oncology, and New England Journal of Medicine. He also serves as the Editor-in-Chief of Clinical Haematology: Best Practice and Research.
Dr. Hua Yu
Dr. Hua Yu is Billy Wilder Endowed Professor, Co-Leader of Cancer Immunotherapeutics Program, City of Hope Comprehensive Cancer Center and Associate Department Chair of Immuno-Oncology. Dr. Yu is a noted expert and pioneer on the cancer-promoting protein STAT3 and was the first to uncover and define the protein’s effect on the immune system. Dr. Yu’s studies have laid the foundation for a new generation of molecular targeted cancer therapy approaches that disable both tumor cells and the tumor stromal cells, which are critical for tumor growth. She has developed potentially paradigm-shifting novel siRNA and antibody delivery technology platforms to inhibit STAT3 and other challenging targets.
Dr. Yu received her bachelor’s and doctoral degrees from Columbia University in NYC. She completed fellowships with the American Cancer Society and the National Institutes of Health. The fundamental discoveries from her laboratory have been well supported continuously by grants from the National Institutes of Health. Her recent studies have been published extensively in such prestigious biomedical/cancer research journals as Nature Medicine, Cancer Cell, Nature Biotechnology, Immunity, Cancer Metabolism and Nature Reviews Cancer and Nature Reviews Immunology.